Food
allergy - a new way to treat food allergy
Researchers showed they revealed Nabil target for the treatment of allergic reactions to foods, where researchers found that levels of the enzyme kinase "Pim1" increases the sensitivity of the small intestine to peanuts in mice, and when inhibition of the activity of this enzyme has said allergic response to peanuts.
The researchers said that this enzyme and transcription factors associated with playing an important role in allergic reactions to peanuts. This provides promising new targets for the treatment of allergic reactions to peanuts and possible other foods.
This enzyme is involved in many of the tracks indicative and is expressed in T cells and , and these types of cells associated with allergic disease. Also associated transcription factor Runx3 with T-cell regulation.
In mice models of the sensitivity of foods, the researchers found that levels of the enzyme kinase pim1 increased in the intestines of mice infected allergic and fed peanuts in addition to many inflammatory cells and molecules Alcetukain levels and injury-related allergies.
And decreased levels of messenger RNA "mRNA" transcription factor clearly in mice infected with allergies. When the researchers give mice small molecules that inhibit the activity of the enzyme did not suffer from any of the mice peanut allergy symptoms such as diarrhea and other symptoms.
And decreased levels of histamine in the blood, causing President for allergy symptoms, after obtaining the inhibitory molecules of the enzyme. And other immune cells rose associated with allergic slightly after eating peanuts.
The researchers said that this data set for the first time that this enzyme contributes in important ways in the pathogenesis of allergic response due to peanuts. And the targeting of this enzyme provides new therapeutic opportunities to control the allergic reactions caused by foods.
Researchers showed they revealed Nabil target for the treatment of allergic reactions to foods, where researchers found that levels of the enzyme kinase "Pim1" increases the sensitivity of the small intestine to peanuts in mice, and when inhibition of the activity of this enzyme has said allergic response to peanuts.
The researchers said that this enzyme and transcription factors associated with playing an important role in allergic reactions to peanuts. This provides promising new targets for the treatment of allergic reactions to peanuts and possible other foods.
This enzyme is involved in many of the tracks indicative and is expressed in T cells and , and these types of cells associated with allergic disease. Also associated transcription factor Runx3 with T-cell regulation.
In mice models of the sensitivity of foods, the researchers found that levels of the enzyme kinase pim1 increased in the intestines of mice infected allergic and fed peanuts in addition to many inflammatory cells and molecules Alcetukain levels and injury-related allergies.
And decreased levels of messenger RNA "mRNA" transcription factor clearly in mice infected with allergies. When the researchers give mice small molecules that inhibit the activity of the enzyme did not suffer from any of the mice peanut allergy symptoms such as diarrhea and other symptoms.
And decreased levels of histamine in the blood, causing President for allergy symptoms, after obtaining the inhibitory molecules of the enzyme. And other immune cells rose associated with allergic slightly after eating peanuts.
The researchers said that this data set for the first time that this enzyme contributes in important ways in the pathogenesis of allergic response due to peanuts. And the targeting of this enzyme provides new therapeutic opportunities to control the allergic reactions caused by foods.
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